Work-related musculoskeletal hazards in a paper-making industry were examined to explore ergonomic interventions in a participatory approach for mitigating the hazards. Manual tasks occurred in this paper-making industry were quite different with ordinary assembly industry where individual workers perform certain specified tasks repetitively. Workers used to perform varieties of team-based irregular manual tasks to interact with the facilities. Among 96 manual jobs investigated, 44 potential hazardous jobs were screened during basic investigation phase and finally 16 hazardous jobs were identified by the detailed analysis phase. The major hazardous factors were awkward postures and excessive weights. Possible ways of intervention were developed, reviewed and proposed by an ergonomics team comprised of staffs and engineers from various departments and ergonomics specialist from outside the company. The proposed intervention ideas were evaluated and modified by the workers and union representatives in terms of usability and comfort. Implemented interventions including mechanization, automation, and improvement of tools and equipments provided fairly promising results.