The objective of this study is to investigate experimentally the characteristics of pressure drop in SMX type motionless mixers. The motionless mixers used are SMX-O, SMX-H, SMXL-O and SMXL-H ones. The SMX-H and SMXL-H mixer elements have been designed to reduce the pressure drop as compared with the SMX-O and SMXL-O ones. The Reynolds number based on the bulk average properties of the water is in a range of 5000 to 13000. The pressure drops across the motionless mixers are measured and the friction factors are calculated using the pressure drop data. On the average, the friction factors of the SMX-H and SMXL-H mixers are about 8% and 15% lower than those of the SMX-O and SMXL-O ones. In addition, the proposed correlations from the experimental data for the friction factor are presented and compared with those obtained from the literature.