Although the acquisition of information may be done individually, knowledge is created from the social context of peers, teachers. And feedback on the appropriateness and effectiveness of their knowledge and skill is commonly received. Learning occures effectively within environment that have shared understanding of problems and various tools to solve problems. The purpose of this study is to apply the main principles of creative Problem solving and develop e-PBL(Problem-Based Learning) to enhance creative problem solving skill. In this research, the group of students who studied by means of e-PBL based on web 2.0 showed much more satisfaction and problem solving skill than the other group of students who did by e-Learning.