108종의 뽕잎 중 청목노상추출물에 의한 LPS로 염증을 유발한 Raw 264.7 세포에서 항염증 효과를 측정한 결과, 청목노상 에탄올추출물 자체는 염증반응에 관여하지 않았으며, 청목노상 에탄올추출물이 LPS 처리에 의해 증가된 염증관련 NO, iNOS, COX-2의 발현을 억제하고, $TNF-{alpha}$의 생성을 억제함으로서 항염증 효과가 있음이 확인되었다.
With extracts from Cheongmoknosang, anti-inflammatory effect was examined in LPS-stimulated Raw 264.7 cells. LPS (10 ng/ml) treatment increased the production of inflammatory cytokines, $IL-1{eta}$, IL-6 and $TNF-{alpha}$ but the ethanol extracts from Cheongmoknosang slightly decreased the production of $TNF-{alpha}$ and also reduced the expression of iNOS and the production of COX-2. It seems that anti-inflammatory effects of ethanol extracts from Cheongmoknosang is partly due to the inhibition of iNOS and COX-2 expression by inhibiting nuclear translocation of $NF-{kappa}B$ and AP-l in Raw 264.7 cells.
