Gallic acid와 linoleic acid의 합성물인 octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate(GA-LA)의 화장품산업에서의 이용 가능성을 알아보기 위하여 유전독성학적 안전성을 확인하고 크림 베이스 유화물을 사용하여 전자공여능, FRAP 및 tyrosinase 활성 억제능력과 같은 GA-LA의 생리 기능성 실험을 실시하였다. 그 결과 유전독성학적 안전성이 확인되었고, 산화에 의한 피부의 노화를 억제하기 위한 항산화 능력과 미백과 관련된 tyrosinase 활성 억제 능력이 있음이 확인되었다. 따라서 GA-LA는 식품산업뿐만 아니라 화장품산업에서 유용한 기능성 물질로 쓰일 수 있을 것이라고 생각되어진다.
The objective of this study was to investigate the genotoxicological safety and biological functions of octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate (GA-LA) in cream-based emulsion for future application as a functional cosmetic material as well as food. GA-LA was synthesized chemically from gallic acid and linoleic acid. The Ames test showed that GA-LA did not have mutagenical toxicity. The control cream-based emulsion containing GA-LA was prepared by commercial method and tested for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Ferric reducing antioxidant power (FRAP) and inhibition effect against tyrosinase of the emulsions were tested for the evaluation of antioxidative and skin-whitening activities. The results showed that DPPH radical scavenging activity in the cream-based emulsion containing GA-LA was higher (52.65%) than that of the control (4.30%). The FRAP value of the sample was 12.85%, however, no activity was found in control. The inhibition effect of tyrosinase showed also a higher value (26.29%) when compared to the control. The results indicate that GA-LA, which showed superior antioxidative and skin-whitening activities in cream-based emulsion, is a useful functional material applicable in cosmetic products as well as food.
