A macroscopic finite element model is applied to investigate the effect of fire induced spalling on the response of reinforced concrete (RC) beams. Spalling is accounted for in the model through pore pressure calculations in concrete. The principles of mechanics and thermodynamics are applied to compute the temperature induced pore pressure in the concrete structures as a function of fire exposure time. The computed pore pressure is checked against the temperature dependent tensile strength of concrete to determine the extent of spalling. Using the model, case studies are conducted to investigate the influence of concrete permeability, fire scenario and axial restraint on the fire induced spalling and also on the response of RC beams. Results from the analysis indicate that the fire induced spalling, fire scenario, and axial restraint have significant influence on the fire response of RC beams. It is also shown that concrete permeability has substantial effect on the fire induced spalling and thus on the fire response of concrete beams. The fire resistance of high strength concrete beams can be lower that that of normal strength concrete beams due to fire induced spalling resulting from low permeability in high strength concrete.