Background and Objective : Wrinkle treatment with oriental medicine is popular these days. But there are few reports about it. This study is performed to introduce wrinkle treatment with oriental medicine. Methods : We searched the oriental literature and reports related with wrinkles and wrinkle treatment. We study about treatment methods with Oriental Medicine like herbal medicines, acupuncture, cupping, moxibustion, etc. Result and Conclusions : Among the treatment method, acupuncture seems to use wound care mechanism. We propose oriental medicine as an effective and beneficial therapy for wrinkle treatment.