An experimental real-time hybrid method, which implements the vibration control of a building structure with only a two-way TLMD, is proposed and verified through a shaking table test. The building structure is divided into the upper experimental TLMD and the lower numerical structural part. The shaking table vibrates the TLMD with the response calculated from the numerical substructure, which is subjected to the excitations of the measured interface control force at its top story and sinusoidal waves input at its base. The results show that the conventional method can be replaced by the proposed methodology with a simple installation and accuracy for evaluating the control performance of a TLMD.