The effects of the diffuser vane on the performances of the multistage centrifugal pump were investigated experimentally, taking account of the interactions among the diffuser vane, the return vane, and the next stage impeller. It is very important to match well the diffuser vane with the return vane, for improving the hydraulic efficiency of the pump. The efficiency may be more improved by making the cross-sectional area of the channel from the diffuser vane outlet to the return vane inlet larger, as much as possible.