Recently, Indoor air quality (IAQ) is one of the most important problem in our daily life of modern societies. Mechanical ventilation system is being recommended as an effective method to improve IAQ in apartment houses. And then, in Korea, building industry should install ventilation system in apartment house by the building construction code. In this study, to improve IAQ caused by microbial and chemical contaminant such as bacteria and TVOC, three types of mechanical ventilation system of apartment house including HRV were simulated by multizone modeling. Simulation results suggest an appropriate and economical renovation method of apartment house ventilation system for reducing indoor air contamination.