Three dimensional coupled bending-torsion dynamic vibrations of thin-walled open section beam subjected to moving vehicle are investigated by transfer matrix method. Through adopting the idea of Newmark-${eta}$ method, the partial differential equations of structural vibration can be transformed to the differential equations. Then, those differential equations are solved by transfer matrix method. An iterative scheme is proposed to deal with the coupled bending-torsion terms in the governing vibration equations. The accuracy of the presented method is verified through two numerical examples. Finally, with different eccentricities of vehicle, the torsional vibration of thin-walled open section beam and vertical and rolling vibration of truck body are investigated. It can be concluded from the numerical results that the torsional vibration of beam and rolling vibration of vehicle increase with the eccentricity of vehicle. Moreover, it can be observed that the torsional vibration of thin-walled open section beam may have a significant nonlinear influence on vertical vibration of truck body.