This paper has dealt with the probability of oyster shell desiccant cooling system driven by renewable energy of photo-volatic effect with fundamental experiment. The test materials for desiccant are activated charcoal, silica-gel, hi-dry, and oyster shell. The experiments were mainly performed with focusing on the observation of surface features, adsorption amounts of the adsorbent species, and the effect of temperature. Oyster shell has sufficient probability for using as desiccant in a air-conditioning system. Moreover, the heat releasing device would be attached in the system, the system based with oyster shell can be operated with high efficiency.