Purpose: This study was done to examine the level of compliance and the relation of related factors of nosocomial infection control among nurses in emergency rooms. The data will provide fundamental information for developing programs for nosocomial infection control in the emergency room. Method: Study participants were 183 nurses working in emergency rooms in general hospitals that had more than 500 beds and were located in Daegu, Daejeun, and Pusan. The survey was carried out from March 7 to March 26, 2006 and a structured questionnaire was used. Descriptive statistics, t-test, ANOVA and Sheffe test with SPSS 14.0 were used to analyze the data. Results: The average level for practice of infection control was relatively low Levels of compliance were high when the participants had: 1) regular conferences for nosocomial infection control, 2) positive perception of protection devices, 3) knowledge of whom to report and experiences of reporting needle stick injuries, 4) hospital guidelines for infection control and 5) enough equipment supplies from the hospital. Conclusion: Nosocomial infection control among emergency room nurses could be improved via personal, psychosocial, and organizational factors and related education.