Purpose: The purpose of this study was to identify the effects of interpersonal relationships and communication curriculum on interpersonal relations and self-esteem. Method: This study employed a two-group pre-post test study design. Data was collected from 70 subjects from April to June, 2006 at C university in Jeju, Korea. Forty subjects were in the control group and 30 subjects were in the experimental group. A structured curriculum was conducted for the experimental group once a week for 12 weeks, but not for the control group. For both groups the scores of interpersonal relations and self-esteem were measured before and after the curriculum. Data was analysed by $X^2$-test, t-test, paired t-test and Pearson correlation with SPSS. Results: The scores of interpersonal relations and self-esteem significantly increased in the experimental group. There were significant positive correlations between interpersonal relationships and self-esteem. Conclusion: In light of these results, interpersonal relationships and communication curriculum have a positive effect on interpersonal relations and self-esteem. Therefore, this study can provide basic data and direction in developing and applying a curriculum in education.