Purpose: The purpose of this study was to investigate the effect of a spirituality/hope promoting program on fighting spirit, helplessness, anxiety, and self-care behaviors. Methods: A nonequivalent control group pretest- posttest design was used. Study subjects were 22 cancer patients undergoing chemotherapy for the experimental group and 31 for the control group. The experimental group received a 4-week intervention, 30-50 minutes a day weekly. Variables were measured at baseline, 4 and 8 weeks later. Fighting spirit and helplessness were measured by MAC(Mental Adjustment to Cancer) and anxiety was measured by Hospital Anxiety and Depression scale. Self-care behaviors scale developed by Oh et al.,(1997) was used. Results: The experimental group revealed significantly more fighting spirit(t=-4.10, p=.000). more self-care behaviors(t=-5.91, p=.000). and less helplessness(t=3.94, p=.000). No difference, however, was found in anxiety between the two groups(t=.24, p=.861). Conclusion: These results suggested positive effects of a spirituality/hope intervention program. Helplessness decreased mainly through an increase in fighting spirit. Self-care behaviors increased mainly through an decrease in helplessness and increase in fighting spirit.