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전립선 비대증 유발 백서에서 복분자를 주성분으로 한 생약제제 KH-305가 미치는 영향
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  • 전립선 비대증 유발 백서에서 복분자를 주성분으로 한 생약제제 KH-305가 미치는 영향
  • The Effect of Herbal Formulation KH-305 Mainly consisted of Rubus Coreanus on Benign Prostatic Hyperplasia-Induced Rat
저자명
김성대,이병희,손동완,조용현,이승민,김정옥,김세웅,Kim. Sung-Dae,Lee. Byung-Hee,Sohn. Dong-Wan,Cho. Yong-Hyun,Lee. Seung-Min,Kim. Jeong-Ok,Kim. Sae-Woo
간행물명
생약학회지
권/호정보
2008년|39권 2호|pp.80-85 (6 pages)
발행정보
한국생약학회
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정기간행물|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Benign prostatic hyperplasia (BPH) is one of the common diseases in elderly men. Recently, the old-aged population has increased, with the interest in the clinical importance of BPH ever growing. This study is designed to investigate the effects of KH-305 on BPH induced rat. The herb formulation KH-305 is consisted of Rubus coreanus, Cornus officinalis and Cuscuta chinensis. An experimental prostatic hyperplasia was induced in male rats by the administration of testosterone propionate, 3 mg/kg SC, for 2 months. The rats were divided into 3 experimental groups: the control, BPH-induced, oral KH-305 ingestion group. After 2 months, the prostates were removed, and analyzed for their prostatic weight and histological examination. The prostate weights were measured in each group, and found to be 820${pm}$38mg, 3140${pm}$26mg, 1880${pm}$21mg in the control, BPH-induced, and oral KH-305 ingestion group, respectively. The BPH induced group showed statistically significant increases in their prostatic weights compared with control group(p<0.05) but oral KH-305 ingestion group showed more significant decreases than BPH-induced group statically(p<0.05). Histologically injected testosterone lead to prostatic hyperplasia in rats, but oral KH-305 ingestion decreased this change. These results suggest that KH-305 may be effective in treatment of BPH, and complementary medicine of BPH.