Synthesis of Bis, Tris and Tetra(dihydrocaffeoyl)polyamine Conjugates as Antibacterial Agents Against VRSA

Synthesis of Bis, Tris and Tetra(dihydrocaffeoyl)polyamine Conjugates as Antibacterial Agents Against VRSA
Synthesis of Bis, Tris and Tetra(dihydrocaffeoyl)polyamine Conjugates as Antibacterial Agents Against VRSA

ㆍ 저자명: Yingyongnarongkul. Boon-Ek,Apiratikul. Nuttapon,Aroonrerk. Nuntana,Suksamrarn. Apichart
ㆍ 간행물명: Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
ㆍ 권/호정보: 2008년|31권 6호|pp.698-704 (7 pages)
ㆍ 발행정보: 대한약학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

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기타언어초록

Bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates were synthesized using solid phase synthesis technique. These compounds were screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Bis, tris and tetra(dihydrocaffeoyl)polyamine analogues showed antibacterial activity against VRSA which were better than the reference drugs, vancomycin. Tetra (dihydrocaffeoyl) polyamine conjugate exhibited the highest activity. These compounds showed no cytotoxicity against vero cells.

키워드

Dihydrocaffeoyl-polyamine conjugates Hydroxycinnamic acid amides Solid phase synthesis Antibacterial activity MRSA VRSA

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