Bioassay-guided fractionation of the MeOH extract of Suaeda glauca yielded four phenolic compounds, methyl 3,5-di-O-caffeoyl quinate (1) and 3,5-di-O-caffeoyl quinic acid (2), isorhamnetin 3-O-$eta$-D-galactoside (3), and quercetin 3-O-$eta$-D-galactoside (4). Compounds 1 and 2 were hepatoprotective against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the $EC_{50}$ values of $72.7{pm}6.2$ and $117.2{pm}10.5;{mu}M$, respectively. Silybin as a positive control showed an $EC_{50}$ value of $82.4{pm}4.1;{mu}M$.