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서지반출
건강한 성인에서 아토르바스타틴 경구흡수과정의 집단약동학 분석
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  • 건강한 성인에서 아토르바스타틴 경구흡수과정의 집단약동학 분석
저자명
채홍석,안병진,한승훈,김지면,도기찬,나현오,임동석,Chae. Hong-Seok,Ahn. Byung-Jin,Han. Seung-Hoon,Kim. Ji-Myon,Doh. Ki-Chan,Lah. Hyon-Oh,Yim. Dong-Seok
간행물명
臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics
권/호정보
2008년|16권 2호|pp.92-100 (9 pages)
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대한임상약리학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Backgrounds: Atorvastatin which has a highly variable pharmacokinetic profileoften shows double peaks. However, in most cases it has been regarded as a noise or assay error. In this study we compared 4 different absorption models (zero order, $1^{st}$ order, combined and parallel absorption model) to determine which model best describes the absorption process. Methods: Plasma atorvastatin data of 57 healthy subjects from two bioequivalence studies were used. Concentrations were measured up to 48 hours after drug administration. Mixed effect analysis to compare the 4 absorption models was performed using NONMEM version 6.0. Results: The absorption process was best described bycombined absorption model. CL/F and Vd/F were 400L/hand 779L, respectively, and KA and D were $0.09;hr^{-1}$ and $0.53;hr^{-1}$, respectively. Conclusion: Although the combined absorption model did not fully describe the double peaks, this study demonstrated that absorption models other than simple first or zero order absorption are necessary to describe the double peaks phenomenon.