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Effect of Poloxamer on the Dissolution of Felodipine and Preparation of Controlled Release Matrix Tablets Containing Felodipine
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  • Effect of Poloxamer on the Dissolution of Felodipine and Preparation of Controlled Release Matrix Tablets Containing Felodipine
  • Effect of Poloxamer on the Dissolution of Felodipine and Preparation of Controlled Release Matrix Tablets Containing Felodipine
저자명
Lee. Kyeo-Re,Kim. Eun-Jung,Seo. Sang-Wan,Choi. Hoo-Kyun
간행물명
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
권/호정보
2008년|31권 8호|pp.1023-1028 (6 pages)
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대한약학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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The effects of poloxamer and HPMC on the dissolution rate of felodipine were investigated and a felodipine controlled release tablet was developed by increasing the water solubility of felodipine and using swelling polymer to control release rate. Milling of felodipine slightly increased the dissolution rate of felodipine when compared with physical mixture. XRD results indicated that felodipine remained in the crystalline form even after co-milling with poloxamer. Improved dissolution rates after co-milling with HPMC and poloxamer were due to both solubilization effect of polymer and milling. The effect of poloxamer on dissolution rate was more significant than that of HPMC. Based on increased solubility of felodipine in the presence of poloxamer, it was concluded that the improved dissolution rate of felodipine was mainly due to a high local concentration of poloxamer around felodipine. Controlled release felodipine tablets were prepared using poloxamer as a solubilizing agent and $Carbopol^{(R)}$ as a controlled release matrix.