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Chiral Separation of Fluvastatin Enantiomers by Capillary Electrophoresis
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  • Chiral Separation of Fluvastatin Enantiomers by Capillary Electrophoresis
  • Chiral Separation of Fluvastatin Enantiomers by Capillary Electrophoresis
저자명
Trung. Tran Quoc,Dung. Phan Thanh,Hoan. Nguyen Ngoc,Kim. Dae-Joong,Lee. Joo-Huyn,Kim. Kyeong-Ho
간행물명
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
권/호정보
2008년|31권 8호|pp.1066-1072 (7 pages)
발행정보
대한약학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

An analytical CE method was developed for the enantiomeric purity determination of fluvastatin enantiomers. Fluvastatin enantiomers were separated on an uncoated fused silica with 100 mM-borate solution containing 30 mg/mL of (2-hydroxypropyl)-$eta$-cyclodextrin (HP-$eta$-CD) as running buffer and fenoprofen as an internal standard. The linearity was observed within a $400-700;{mu}g/mL$ concentration range ($r^2{geq}0.995$) for both fluvastatin enantiomers. The repeatability expressed as coefficient of variation (CV) of the method were 0.96 and 0.92% for (+)-3R, 5S and (-)-3S, 5R-fluvastatin, respectively. The limit of detection and quantification for both fluvastatin enantiomers were $1.5;{mu}g/mL$ and $2.5;{mu}g/mL$, respectively.