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허혈성 뇌손상 백서에서 가감총명탕(加減聰明湯)이 인지기능에 미치는 효과
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  • 허혈성 뇌손상 백서에서 가감총명탕(加減聰明湯)이 인지기능에 미치는 효과
저자명
김경윤,김형우,이상영,차대연,이석진,김계엽,김행중,정현우,Kim. Kyung-Yoon,Kim. Hyung-Woo,Lee. Sang-Yeong,Cha. Dae-Yeon,Lee. Seok-Jin,Kim. Gye-Yep,Kim. Han
간행물명
동의생리병리학회지
권/호정보
2008년|22권 3호|pp.556-561 (6 pages)
발행정보
대한동의생리학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

ChongMyeong-Tang (CMT) have been used clinically to treat patient with amnesia and dementia. In addition, CMT have been also used for examinee to improve learning ability in Korea. This study was designed to investigate the effects of Gagam-ChongMeong-Tang (GCMT) on cognitive dysfunction recovery after ischemic brain injury in rats. Rats were divided into three groups; (1) normal, (2) commercial diet after ischemic brain injury (control), (3) CMT diet after ischemic brain injury (experiment). In our study, we carried out Morris water maze test for cognitive motor behavior test and immunohistochemistry study through the change BDNF in the hippocampus($7^{th},;14^{th};day$). In Morris water maze test, cognitive motor function recovery was significantly increased in the experiment group as compared with control group on $7^{th};and;14^{th};day$ day (p<0.01). In immunohistochemistric response of BDNF in the hippocampus, more immune reaction was investigated in the experiment group as compared with control group on $7^{th};and;14^{th};day$. Especially more immune reaction was experimented $14^{th}$ day. These results imply that GCMT can play a role in facilitating recovery of cognitive function after ischemic brain injury in rats.