The present study is mainly motivated to investigate the vaporization, auto-ignition and combustion processes in high-pressure diesel engines. In order to realistically simulate the dimethyl ether (DME) fueled diesel engine, the high pressure vaporization model is utilized and the interaction between turbulence and chemistry is treated by employing the Representative Interactive Flamelet (RIF) model. The detailed chemisty consisted of 336 elementary reaction steps and 78 species is used for DME/air reaction. Numerical results indicate that the RIF model with high pressure vaporization model successfully predicts the essential feature of the combustion processes and pollutants formations in the DME fueled diesel engines.