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이진탕(二陳湯)이 STZ 유발(誘發) 당뇨병(糖尿病) 흰쥐의 위(胃) 운동성(運動性)에 미치는 영향(影響)
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  • 이진탕(二陳湯)이 STZ 유발(誘發) 당뇨병(糖尿病) 흰쥐의 위(胃) 운동성(運動性)에 미치는 영향(影響)
  • Effect of Yijin-tang on Gastric Motility in STZ-Induced Diabetic Rats
저자명
허원영,윤상협,Hur. Won-Young,Yoon. Sang-Hyub
간행물명
대한한방내과학회지
권/호정보
2008년|29권 1호|pp.67-79 (13 pages)
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대한한방내과학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Backgrounds & Objectives : The aims of this study were to observe how morphology was changed and whether gastric motility was impaired in streptozotocin(STZ)-induced diabetic rats(DR), and whether Yijin-tang(YJT) was able to restore their impaired gastric motility. Methods : We investigated the change of body weight, feed intake and blood glucose between normal rats (NR) and DR for 12 weeks after induction of diabetes. At the time of 12 weeks after induction of diabetes, gastric surface area, gastric slow wave and gastric emptying rate were measured. Results : Decreased body weight, increased feed intake and increased gastric surface area were observed in DR, compared with NR. The percentage of normogastria decreased but that of bradygastria increased in DR, compared with NR. YJT 90mg/kg had no effect on the correction of gastric slow wave. YJT 90mg/kg and 270mg/kg had a significant effect on improvement of gastric emptying, more than normal saline (NS) in both NR and DR but the gastric emptying rate of DR was significantly lower than that of NR when YJT 90mg/kg and YJT 270mg/kg were administered. Conclusions : We can expect that administration of YJT would be effective on the improvement of gastric emptying and upper gastrointestinal symptoms as a juvantia.