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Bisphosphonate-related osteonecrosis of the jaw의 병리조직학적 소견 및 방사선학적 특징에 대한 임상적 고찰
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  • Bisphosphonate-related osteonecrosis of the jaw의 병리조직학적 소견 및 방사선학적 특징에 대한 임상적 고찰
저자명
오주영,권용대,김여갑,이백수,윤병욱,최병준,Ohe. Joo-Young,Kwon. Yong-Dae,Kim. Yeo-Gab,Lee. Baek-Soo,Yoon. Byoung-Wook,Choi. Byoung-Jun
간행물명
大韓口腔顎顔面外科學會誌
권/호정보
2008년|34권 5호|pp.550-554 (5 pages)
발행정보
대한구강악안면외과학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Bisphosphonates (BPs) are a class of agent used to treat patient with osteoporosis or malignant bone metastases. BPs can be categorized into 2 groups: nitrogen-containing and non-nitrogen containing. Nitrogen-containing BPs are considered to have more toxicity. Despite their clinical benefits, bisphosphonate-related osteonecrosis of jaw(BRONJ) is a significant complication to patients receveing these drugs. Since the first description of BRONJ in 2003 by Marx, the number of reports on BRONJ has been rapidly increasing. BRONJ is considered as an emerging problem in oral & maxillofacial surgery. Generally, osteonecrosis in the maxilla is rare, however BRONJ is found both in the maxilla and the mandible. This is an important feature of BRONJ compared to common infectious osteomyelitis of the jaw. Growing number of case reports, suggest that bisphosphonate therapy may cause exposed, necrotic bone. BRONJ has simillar features compared to IORN (infected osteoradionecrosis). BRONJ has meaningful features established through the interestigation on histopathologic and radiographic findings. These features have an impact on treatment plan and prognosis. This presentation contemplates on features of histopathologic and radiographic findings in bisphosphonate-related osteonecrosis of the jaw.