With the increasing demand for higher production quality and growing competition in the global market, coordinate measuring machine(CMM) has been widely used in industry to improve the efficiency and effectiveness of measurement. In this paper the performance evaluation of coordinate measuring machine is proposed using design of experiments. A factorial design is applied to carry out the performance test proposed by ISO 10360 with a length bar and to investigate CMM measurement errors associated to orientation and length in the work volume. The determination of the significance of effects in an experiment is made through the analysis of variance(ANOVA). The results show that the proposed method is suitable to analyze the factors which affect the CMM measurement performance.