Purpose: The aim of this study was to testify effectiveness and adaptability of the job characteristics model in nursing organization. Methods: The subjects of this study were 250 nurses who were working in the 2 general hospitals located in Metropolitan city area. The data were collected by self-reporting questionnaires. The data were analyzed using descriptive statistics and path analysis. Results: The modified path model revealed a highly fitness of the data in the overall fitness indexes. The prediction power of modified model was from 44% to 58%, which was very high. The highest predict factors of organizational commitment were identified meaning of empowerment and feedback of job characteristics. The highest predict factors of job satisfaction were identified impact of empowerment and autonomy of job characteristics. Conclusion: With these findings, it was suggested that the nursing job-redesign plan focused on nursing feedback and autonomy among the job characteristics was needed to increase the nurse’ empowerment as well as nursing organizational effectiveness.