This paper presents a case history on failures of impeller and shaft due to pressure pulsation at single stage feed water pumps in 700 MW nuclear power plant during commissioning operation. The pumps had been service and had run for approximately $40{sim}50$ hours. For the most part, the failures of impeller occurred with the presence of a number of fatigue cracks. All cracks were associated with the deleterious surface layer of impeller by visual and metallurgical examination. On-site testing and analytical approach was performed on the systems to diagnose the problem and develop a solution to reduce the effect of exciting sources. A major concern at high-energy centrifugal pump is the pressure pulsation created from trailing edge of the Impeller blade, flow separation and recirculation at centrifugal pumps of partial load. Pressure pulsation due to the interaction generating between impeller and casing coincided with natural frequencies of the impeller and shaft system during 1ow load operation. It was identified that dynamic stress exceeding the fatigue strength of the material at the thin shroud section due to the hydraulic instability at running condition below BEP.