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Effect of Hydrophobic Excipients on the Properties of Fast Disintegrating Tablets
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  • Effect of Hydrophobic Excipients on the Properties of Fast Disintegrating Tablets
  • Effect of Hydrophobic Excipients on the Properties of Fast Disintegrating Tablets
저자명
Jeong. Seong-Hoon,Park. Ki-Nam
간행물명
藥劑學會誌
권/호정보
2008년|38권 5호|pp.303-311 (9 pages)
발행정보
한국약제학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Highly hydrophobic lubricants including magnesium stearate may hinder water penetration into the tablet core resulting in delayed disintegration of fast disintegrating tablets. Alternative lubricants with equivalent lubricating properties may need to be incorporated into the tablet formulations. Sodium stearyl fumarate, glyceryl behenate and polyethylene glycol were evaluated regarding the tablet ejection energy, mechanical strength and disintegration time using Texture analyzer (TA). Resulting tablets were also compared with different particle sizes of granules and various compression forces. Among the tested lubricants, sodium stearyl fumarate was less sensitive to mixing time and also showed better or competitive tablet properties. During the experiments, TA was found to be very useful tool to investigate the tablet properties.