Manta-type Unmanned Undersea Test Vehicle(MUUTV) is based on the same design concept as Unmanned Undersea Vehicle called Manta Test Vehicle(MTV), which was originally built and operated by the Naval Undersea Warfare Center(Lisiewicz et al., 2000, Sirmalis et al. 2001). The authors carried out the sensitivity analysis of the response of manoeuvring motion of MUUTV to changes in hydrodynamic derivatives, In order to calculate the sensitivity indices of hydrodynamic derivatives on MUUTV, the method by Sen(2000) was adopted Basically the dynamic mathematical model with six degrees of freedom by Feldman(1979) is used but a little revised, refered to Sohn et al.(2006) and some experiment in circulating water channel. Through the present research, some hydrodynamic derivatives of significance are found out, and also the numerical simulation using simplified mathematical model based on result of sensitivity analysis is ascertained to be enough for prediction of manoeuvring characteristics of MUUTV.