Interior space in most buildings is divided into several zones. The most important factors relating to the indoor air environment are temperature, airflow, humidity, and contaminant concentration. An integrated multizone model to predict these environmental factors simultaneously was developed. Also, a computer program for this model was written by the language of VISUAL BASIC. The proposed model was applied to a apartment with five rooms that had been tested by Chung. Comparison of predicted results by this study with measured results by Chung showed that their variations were within 14% for airflow rates, 1% for temperatures, 12% for humidities, and 5% for concentrations. It was seen that the opening operation schedule of building has a significant effect on the air moisture md contaminant removal. Thus, this model may be available for predicting the indoor air environment and may be contributed to design the ventilation plan for controling of indoor air quality.