The ytterbium catalyst immobilized on the cross-linked poly(4-vinylpyridine/styrene) copolymer (P/S-Yb) was applied in the Mannich-type, three component one-pot synthesis of $eta$-aminoketones. This catalytic system showed excellent catalytic activity and selectivity which resulted in the exclusive formation of $eta$-aminoketone. The applicability of this immobilized catalyst system was shown by the reusability test and again highlighted by the synthesis of a $eta$-aminoketone library using a broad range of substrates.