In this paper, the technique to reinforce the durability performance of structure using the sensitivity information for the frame structure is applied. The fatigue life calculation for the frame structure is performed from the quasi-static and transient analysis and the characteristics of two methods are compared for the fatigue analysis. Then the reinforcement technique is applied. First, some design variables related to the locations of fatigue failure is selected. Then sensitivities of fatigue life at fracture points with respect to the variation of design variables are calculated and the vector composed of gaps between the target life and initial life cycles is calculated. If the number of fatigue fracture points is same as the number of design variables, the variations of the design variables are calculated from the linear algebraic equation. If not, the variations of the design variables are calculated from the optimization formulation with the constraints.