The purpose of this study was to investigate the effects of combined exercise program and garlic pill intake on Body Composition, CRP and Adiponectin in obese high school male students. Twenty-one male students in city B volunteered to participate, and the signed consents were received before the study. Experimental groups were garlic pill intake with combined exercise group (n=7), combined exercise group (n=7), control group (n=7). The total experimental period was 16 weeks. The combined exercise group exercised 3 times a week for 16 weeks with intensity of RPE 7~15. Each exercise was 70 minutes long. A 5 g garlic pill was consumed after lunch and dinner every day. For statistics, two-way repeated test within the group was conducted through SPSS 12.0; for post-examination, Scheffe was utilized; and for inter-group examination, a paired t-test was used. The conclusions of this study are as follows. Between groups, combined exercise with garlic pill group had a significant decrease in %body fat. Within each group, combined exercise with garlic pill group had a significantly greater decrease in %body fat than the control group. Between groups, combined exercise with garlic pill group had a significant decrease in LBM. Between groups, combined exercise with garlic pill group had a significant decrease in CRP. Between groups, combined exercise with garlic pill group, combined exercise and control group showed a decrease in adiponectin. In conclusion, regular exercise and garlic pill intake improved % body fat in obese high school male students.