Electrolyzed reduced water was known as an alkaline solvent than piped water, natural water and mineral water etc. By means of reduction property, electrolyzed reduced water could dissolve a solute than other kinds of water without chemicals. In this study, serpentine dissolution in electrolyzed reduced water was investigated as a novel pre-treatment of serpentine which was a minerals for carbon dioxide sequestration. The elements (Ca, Si, Mg etc.) of serpentine were dissolved rapidly at early in the dissolvation then after some minutes the solubilities of serpentine elements showed stable state without abrupt changes. In spite of serpentine elements dissolution, chemical bondings and crystallographic structure of serpentine were not changed. It was explained that the dissolution mechanism of serpentine occurred from surface in electrolyzed reduced water and bulk structure sustained without collapse.