This study aims to provide an optimal model for the layout of multiple tower cranes and material stockyards which have multiple candidate positions. In a high-rise building construction, the positional allocation of tower cranes and material stockyard has an effect on the travel time of material hauling. In addition, in case of using multiple tower cranes, specific location of a tower crane allocated to each material determines the efficiency of the works. Current optimal model limited to the optimization of position of single tower crane and material stockyards. This study suggests optimal model both for the positions of multiple tower cranes and material stockyards. Layout of multiple tower cranes requires additional allocation of each crane to each material hauling and control on the minimum distance between tower cranes. This optimization model utilizes genetic algorithm to deal with complex interaction on the candidate positions of multiple tower cranes, material stockyards, and types of materials. In order to identify its utility, case study was performed.