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서지반출
Parenteral Docetaxel Emulsion System and Its Stability
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  • Parenteral Docetaxel Emulsion System and Its Stability
  • Parenteral Docetaxel Emulsion System and Its Stability
저자명
Kim. Hyun-Jo
간행물명
藥劑學會誌
권/호정보
2009년|39권 1호|pp.13-18 (6 pages)
발행정보
한국약제학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Docetaxel is an anticancer agent with low aqueous solubility. More extensive clinical use of this drug is somewhat delayed due to lack of appropriate delivery vehicles. An attempt was made to adopt an o/w emulsion as the drug carrier which incorporated docetaxel in the propyleneglycerol stabilized by a mixed-emulsifier system. A suitable formulation was found in this study: 10 mg/mL docetaxel, 10% (w/v) oil blend, 4% (w/v) PG, 3% (w/v) Solutol HS 15 in 2.25% (w/v) glycerol solution. The formulated emulsion has very good stability when stored at $40^{cird}C$, and the docetaxel containment efficiency can be maintained above 95% and the mean emulsion diameter around $10{mu}m$ for at least 3 months. The formulated emulsion is a promising carrier for docetaxel and other lipophilic drugs.