- Parenteral Docetaxel Emulsion System and Its Stability
- Parenteral Docetaxel Emulsion System and Its Stability
- ㆍ 저자명
- Kim. Hyun-Jo
- ㆍ 간행물명
- 藥劑學會誌
- ㆍ 권/호정보
- 2009년|39권 1호|pp.13-18 (6 pages)
- ㆍ 발행정보
- 한국약제학회
- ㆍ 파일정보
- 정기간행물|ENG| PDF텍스트
- ㆍ 주제분야
- 기타
Docetaxel is an anticancer agent with low aqueous solubility. More extensive clinical use of this drug is somewhat delayed due to lack of appropriate delivery vehicles. An attempt was made to adopt an o/w emulsion as the drug carrier which incorporated docetaxel in the propyleneglycerol stabilized by a mixed-emulsifier system. A suitable formulation was found in this study: 10 mg/mL docetaxel, 10% (w/v) oil blend, 4% (w/v) PG, 3% (w/v) Solutol HS 15 in 2.25% (w/v) glycerol solution. The formulated emulsion has very good stability when stored at $40^{cird}C$, and the docetaxel containment efficiency can be maintained above 95% and the mean emulsion diameter around $10{mu}m$ for at least 3 months. The formulated emulsion is a promising carrier for docetaxel and other lipophilic drugs.