This study proposes the structural optimization of a manifold valve. FE analysis is performed to evaluate the strength of a manifold valve. In addition, the structural optimization technique is applied to reduce its weight. In this study, the optimization method using the kriging interpolation method is adopted to obtain the minimum weight satisfying the strength constraint. The maximum stress and the weight are replaced by the metamodels. In this process, tile sample points are generated by latin-hypercube design. Optimum designs are obtained by ANSYS Workbench and the in-house program.