Objectives: This study is a quasi-experimental research with nonequivalent control group pretest-posttest design study to compare and verify the educational effects between CPR Song.Video Self-Instruction and CPR VSI. Method: We selected total 58 subjects who were freshmen at the Dept of Emergency Medical technology, G College in G Metropolitan City and 28 of them were experimental group which had no experience to have CPR instruction and consented to take part in this research and 30 students were control group. Data were collected from Apr. 27 to 29, 2009. Data were analyzed with SPSS/PC+(version 14.0). and all significance level was set as p<0.05. Results: 1. In the knowledge of CPR, the knowledge level before CPR instruction was 2.17 out of 10 in experimental group and 1.86 in control group. After CPR instruction, experimental group got 9.07 and it meant the increase of 6.89 and control group showed increase to 7.16(p=0.000). 2. Self-efficacy of CPR showed 2.61 out of 10 in both experimental and control groups, and after CPR instruction, experimental group showed increase of 3.93 as 6.55 and control group showed increase of 3.91 as 6.52(p=0.000). 3. Accuracy of CPR performance was 0.32 out of 10 in experimental group and 0.40 in control group. After CPR instruction, experimental group got 9.25 and showed increase of 8.92 and control group got 9.20 and showed increase of 8.80(p=0.000). 4. Study satisfaction was 4.22 out of 5 in experimental group and 3.04 in control group, and experimental group was higher than control group. there was no statistically significant difference. Conclusions: This study found that CPR Song；Video Self-Instruction achieved better results than CPR VSI. With these results, it is considered that CPR instruction for college students through mass communication or video will be very helpful.