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CELL MORPHOLOGY CHANGE BY THE ULTRAVIOLET RAY IRRADIATION
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  • CELL MORPHOLOGY CHANGE BY THE ULTRAVIOLET RAY IRRADIATION
  • CELL MORPHOLOGY CHANGE BY THE ULTRAVIOLET RAY IRRADIATION
저자명
Park. Myoung-Joo,Matuo. Yoichirou,Akiyama. Yoko,Izumi. Yoshinobu,Nishijima. Shigehiro
간행물명
방사선방어학회지
권/호정보
2009년|34권 1호|pp.15-24 (10 pages)
발행정보
대한방사선방어학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The effect of low doses of ultraviolet (UV) irradiation on morphology changes of cell has been studied based on the observation of the cell length. It was shown that UV-irradiated cell has different behavior in comparison with non-irradiated cell. From the histogram of cell-length distribution, it was confirmed that cell cycle of non irradiated cell was 28 hours, and that cell cycle of irradiated cell with dose of $20;Jm^{-2}$ was delayed (39 hours), while irradiated cell with $40;Jm^{-2}$ and $60;Jm^{-2}$ did not divide and kept growing continuously. It was supposed that in case of $20;Jm^{-2}$ of irradiation dose, the cell cycle was delayed because the checkpoint worked in order to repair DNA damage induced by generation of pyrimidine dimer, reactive oxygen species and so on. It was also supposed that in case of $40;Jm^{-2}$ and $60;Jm^{-2}$ of irradiation dose, overgrowth was induced because the checkpoint was not worked well. The morphology of overgrown cell was similar to that of normally senescent cell. Therefore, it was considered that cell senescence was accelerated by UV irradiation with irradiation doses of $40;Jm^{-2}$ and $60;Jm^{-2}$.