Purpose: This study compared health behaviors between single-member and multiple-member households by gender in adults. Method: Study subjects were 21,757 adults 20-65-years-of-age from the Third Korea National Health and Nutrition Examination Survey in 2005. The relationship between health behaviors and residence characteristics was assessed using multiple logistic regression analysis while controlling for sociodemographic characteristics. Results: Younger women living alone were more likely to drink than older women living with others. Women who were in multiple-member households and had a low income were less likely to exercise regularly, to sleep well, and to have regular health examinations. Age, educational level, and income were significantly associated with smoking, exercise, and health examination rather than residence characteristics in men. Conclusion: Residence characteristics should be considered in developing a public health program to reduce or increase modifiable health behaviors as well as age, gender, education, and income.