This study is concerned with predicting human search performance using a visual lobe. The most previous studies on human performance in visual search have been limited to a single-target search. This study extended the visual search research to multiple-target search including targets of different types as well as targets of same types. A model for predicting visual search performance was proposed and the model was validated by human search data. Additionally, this study found that human subjects always did not use a constant ratio of the whole visual lobe size for each type of targets in visual search process. The more conspicuous the target is, the more ratio of the whole visual lobe size human subjects use. The model that can predict human performance in multiple-target search may facilitate visual inspection plan in manufacturing.