Myxoma is a benign mesenchymal neoplasm that can occur in the head and neck. Laryngeal myxoma is extremely rare and easily confused with a laryngeal polyp. The common clinical presentation is hoarseness, dysphonia, dyspnea and dysphagia depending on their size and location. Treatment for laryngeal myxoma is complete surgical excision with surrounding normal tissue. To our knowledge, 11 laryngeal myxomas have been reported in the English literature, and all patients except only 1 case were male. We report the second female case of myxoma on a vocal cord with a review of literature.