Purpose: The present study was performed to evaluate the effect of hydroxyapatite dental paste on tooth hypersensitivity compared to other materials. Materials and methods: In the general fluoride dental paste, strontium fluoride dental paste and hydroxyapatite dental paste, patient-performed VAS and VAS(ice test) were measured at baseline, 1weeks and 4weeks. Results: 1. In patient-performed VAS, there were significant differences reducing of tooth hypersensitivity between general fluoride toothpaste and hydroxyapatite toothpaste. 2. In operator-performed VAS(ice test), there were significant differences reducing of tooth hypersensitivity among each group, between general fluoride toothpaste and hydroxyapatite toothpaste and between general fluoride toothpaste and strontium fluoride toothpaste. Conclusion: In conclusion, hydroxyapatite toothpaste can be applied for control of tooth hypersensitivity.