This article investigates economic-statistical design of VSSI(variable sampling size and interval) cause-selecting charts considering two assignable causes. We consider a process which is composed of two dependent sub-processes. In each sub-process, two kinds of assignable cause may exist. We propose a procedure for designing VSSI cause-selecting charts, based on Lorenzen and Vance model. Computational experiments show that the VSSI cause-selecting chart is superior to the FSSI cause-selecting chart in the economic-statistical characteristics, even under two assignable causes.