This paper presents an optimization of the industrial guide-way vehicle that aims to improve running stability at increased speeds. A guide-way vehicle was used to transfer products in various manufacturing industries. Using Design Of Experiment(D.O.E.), the design prototype was optimized. The improved design prototype and its design parameters were obtained by a case study determined by the engineering discussion. The computational model for the optimization was validated by correlation with the test results. Through this procedure, the optimization method presented in this paper has been proven to be effective.