A systematic reliability evaluation approach for torsional divergence analysis of long span suspension bridges is proposed, consisting of the first order reliability method and a simplified torsional divergence analysis method. The proposed method was implemented in the deterministic torsional divergence analysis program SIMTDB through a new strategy involving interfacing the proposed method with SIMTDB via a freely available MATLAB software tool (FERUM). A numerical example involving a detailed computational model of a long span suspension bridge with a main span of 888 m is presented to demonstrate the applicability and merits of the proposed method and the associated software strategy. Finally, the most influential random variables on the reliability of long span suspension bridges against torsional divergence failure are identified by a sensitivity analysis.