The effect of cellulolytic (Viscozyme) and pectolytic (Pectinex) enzyme treatments on extraction of total polyphenol and antioxidant activity of extract from apple peel have been examined. Extraction was carried out with a dosage of 0.1, 0.25, 0.5, 1 and 2% (v/v) of Viscozyme, Pectinex and Viscozyme+Pectinex at $30{sim}50^{circ}C$ for $12{sim}24$ hours. Total polyphenol contents (mg/mL) of extracts obtained with 2% of Viscozyme, Pectinex or Viscozyme+Pectinex treatment for 12 hours were $0.30{pm}0.02$, $0.16{pm}0.01$, and $0.33{pm}0.02$ at $30^{circ}C$, $0.34{pm}0.01$, $0.19{pm}0.01$, and $0.35{pm}0.02$ at $40^{circ}C$ and $0.34{pm}0.01$, $0.22{pm}0.01$, and $0.38{pm}0.02$ at $50^{circ}C$ respectively. The result shows that Viscozyme was more effective than Pectinex at all experimental temperatures, and Viscozyme+Pectinex resulted in the highest phenolic content at $50^{circ}C$. Antioxidant activities determined by DPPH, ABTS and FRAP assays were increased with concentrations of extracts produced by 2% of Viscozyme+Pectinex treatment, which ranged from 0.10 to 0.40 vit. C eq mM for $5{sim}25;mg$ of dried matters, from 0.09 to 0.28 vit. C eq mM for $1{sim}5;mg$ of dried matters, and from 0.06 to 1.85 $FeSO_4$ eq mM for $1{sim}5;mg$ of dried matters, respectively.