The reliability assessment is performed for Pressure Control Regulator of Aircraft Fuel System using reliability procedure which consists of the reliability analysis and the Failure Modes and Effects Analysis(FMEA). The target reliability as MTBF(Mean Time Between Failure) is set to 5000hr. During the reliability analysis process, the system is categorized by Work Breakdown Structure(WBS) up to level 3, and a reliability structure is defined by schematics of the system. Since the components and parts that have been collected through EPRD/NPRD. The predicted reliability to meet mission requirements and operating conditions is estimated as 4375.9hr. To accomplish the target reliability, the components and parts with high RPN have been identified and changed by analyzing the potential failure modes and effects. By changing the configuration design of components and parts with high-risk, the design is satisfied target reliability.