The spindle is the main component in machine tools. The static and dynamic stiffness of the spindle directly affect the machining productivity and surface integrity of the workpiece. The static and dynamic stiffness of the spindle depend on the shaft size, bearing arrangement, bearing span length, and so on. Therefore, the selection of shaft size and bearing span length are important to improve the spindle stiffness. This paper presents the determination of shaft size and bearing span length in spindle design step. In order to select the optimal bearing and built-in motor locations with constraint conditions, the extreme vertices design was applied. The results show that extreme vertices design is usable for spindle design with design constraints.